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Yamuna Krishnan now at the University of Chicago and Dr. Her predecessors, Souvik Modi and Dhiraj Bhatia, are also recipients of the award.
While Souvik studied the DNA-based pH sensor in cultured cells, my work took it a step beyond, by testing the sensor in a living organism, the nematode C.
The DNA-based pH sensor has been used to study chemical correlates of cellular transport by monitoring changes in acidity during the process of endocytosis the process by which cells engulf materials from their environment.
The process started from within a test tube, where the ensemble of DNA and fluorophores compounds that emit light of a certain frequency on excitation with light of a higher frequency were assembled into a sensor. The sensor was then injected into the body cavity of the worm, where it was found to be specifically taken up by coelomocytes, the scavenger cells in C.
Once inside these cells, the pH sensor now allowed tracking of temporal and spatial changes in acidity through changes in fluorescence. A part of this investigation also established that the negative charge on the DNA backbone of the sensor was a key factor in its binding to a protein receptor on the coelomocyte surface.
For testing and validating the functioning of this pH sensor, C. Further, the research established a method to assess the stability of a variety of DNA nanostructures in the worm and demonstrated that this assay captures differences between stabilities of different DNA architectures.
This paved the way for determining timescales up to which measurements using a sensor made of a DNA nanostructure could be made quantitatively.
Conceptualizing an idea is easy - but much of the work lies in the ability to implement the idea. She worked across two labs, dealing with two principal investigators - teaching me genetics and Sandhya chemical biology.
Sunaina faced at least three huge obstacles at completely different stages in her thesis work where most PhD students would have given up and changed their projects. She showed tremendous grit, tried a hundred different things, dug her claws in, and made a remarkable achievement for the field of DNA nanotechnology.
I have been very lucky to have mentored a her along with a whole batch of extraordinarily driven and creative students at NCBS, whose passion for non-safe science has taken them places", says Dr.
I am very happy that I got the Eli Lilly award", exclaims Sunaina. I will not be using the DNA-sensor techniques I worked on right away - I would like to consider and look into other available technologies in this field.
However, DNA sensors give one such a unique handle in addressing questions, that they are a definite possibility for the future", she says.
The Eli Lilly and Company Asia Outstanding Thesis Awards are prizes given to the top twenty PhD theses in India that have made significant contributions in the field of medicinal chemistry, organic synthesis, computational chemistry, structural biology or analytical chemistry.The Eli Lilly and Company Asia Outstanding Thesis Awards are prizes given to the top twenty PhD theses in India that have made significant contributions in the field of medicinal chemistry, organic synthesis, computational chemistry, structural biology or analytical chemistry.
Archives and past articles from the Philadelphia Inquirer, Philadelphia Daily News, and schwenkreis.com But the government pricing regulations under discussion are very different from the FDA regulations that are causing the problem. The writer of this article may oppose those regulations, and be taking them as fixed, saying that given their existence, medical prices must be controlled.
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Cezarija Abartis. Cezarija Abartis’ Nice Girls and Other Stories was published by New Rivers Press. Her. National Organic Symposium Trust (NOST) invites nominations for ‘ Eli Lilly and Company Asia Outstanding Thesis Awards’ from Ph.D. scientists who have submitted their thesis and made significant contributions in the field of medicinal chemistry, organic synthesis, computational chemistry, structural biology or analytical chemistry.
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